An AC Hotel by Marriott with 156 rooms is being planned at 3400 Biscayne Boulevard.
Midtown Inn, built in 1953 with 36 rooms, will be demolished to make way for the new hotel.
Next door, a 142-room Hampton Inn and Suites being built by the same developers is nearing completion. It is scheduled to open in September.
Kobi Karp is the architect for both hotels.